Endocrine Abstracts

Introduction: An insulin therapy protocol (ITP) was created during 2007 in our hospital by endocrinologists, internal physicians and nurses. The aim was to establish the basal-bolus therapy as the treatment for the non-critical diabetic in-patients in order to ease the management and lead a better glycemic control of these patients. A poster was presented to all the hospital departments in several meetings during 2008. This poster showed the way to calculate the initial insuli...

Objectives: To valuate the insulin treatment intensification efficacy (from three premixed insulin doses to basal-bolus therapy) in type 1 and 2 diabetic patients wrongly controlled.Material and methods: The 61 patients were included. 29 (47.5%) type 1 diabetes mellitus (DM) and 32 (52.5%) type 2 DM, attended in the Day Diabetes Hospital (DDH) during 2008. 50.8% were females and 49.2% were males. Mean age was 34.2±14.4 in type1 DM and 63.6±8.6 ...

Objectives: The daily diabetes hospital (DDH) is a functional device that offers to diabetics a close and customized attention by specialized staff. The objective is to evaluate the welfare activity, the diagnose and educative program of the DDH in 2007.Methodology: The following parameters have been analyzed: attended users, origin, main reason for consultation, previous Hba1c and to the 3 months, number revisions, income avoided, derivation place, tele...

Introduction: Currently self-glycemic control by the patient is essential to achieve a right metabolic control of diabetes. Nowadays, there are different systems that have proved useful for this aim.Objectives: Valuing any possible differences between systems and the relation with glycemia identified in our laboratory.Material and methods: We took blood samples by vein-puncture to 41 patients, and simultaneously we measured capilla...

Loss of function of succinate dehydrogenase (SDH), caused by mutations in each of the 4 subunits – SDHA/B/C and D – is associated with development of phaeochromocytomas and paragangliomas (PPGLs). The mutations lead to loss of enzymatic activity and subsequent accumulation of the oncometabolite succinate, a driver of tumourigenesis. It is well established but poorly understood why mutations in SDHB are associated with more aggressi...

Introduction: Sclerostin, produced by osteocytes, is a potent inhibitor of Wnt signaling and bone formation. The usefulness of its determination in clinical practice is not well established.Objectives: The aims of this study were to evaluate serum sclerostin levels in a cohort of Spanish posmenopausal women, and to analyze its relationship with bone metabolism.Methods: We measured serum sclerostin in 97 posmenopausal women using EL...

Objective: To develop a specific questionnaire to evaluate the satisfaction of diabetic patients with the use of glucometers and evaluate their psychometric properties (feasibility, reliability, and validity).Material and methods: Two stages: i) questionnaire development: a set of 53 items was constructed after a bibliographic review. A panel of six experts and 50 patients concluded a 25-item version of the questionnaire (dimensions: satisfaction, inconv...

Introduction and objectives: In clinical practice many professionals are involved in the diabetes treatment. To facilitate this work, we present a computer program, based in recommended guidelines, to improve the management of insulin therapy, called insulinator. We evaluated the correlation between these and clinical practice.Materials and methods: Insulinator has been made so that using a number of variables (weight, HbA1c and glycemic control) offer a...

The Liver X Receptor (LXR) agonists have been shown to influence the development of hyperlipidemia and atherosclerosis in mouse models. It has also been demonstrated that some LXR agonists can cause hepatic steatosis in experimental animals. GH is also known to regulate hepatic metabolism and absence of the hepatic GH receptors leads to hepatic steatosis. In this study we analyzed whether actions of LXR agonists could involve interference with GH signaling. We showed that LXR ...

Objectives: Our aim is to assess the cardiovascular risk factors that are already present at the time of diagnosing new-onset type 2 diabetes mellitus (DM).Materials and methods: This was an observational study. From each patient the following data were retrospective collected between January 2008 and September 2009: age, sex, DM in the family, smoking, HbA1c, hypertension (HTA) and dyslipidemia, microangiopathy and macroangiopathy, lipids and medical tr...